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Zoxazolamine (INN)

CAS 61-80-3
10

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Zoxazolamine (inn) is a cosmetic ingredient. Exercise caution due to limited available safety data.

Zoxazolamine was a uricosuric agent and muscle relaxant drug previously investigated for gout and spasticity treatment. EU Annex III of the Cosmetics Regulation prohibits its use in cosmetic products at concentrations ≥0.1% as a substance or in mixtures. Toxicological data show acute toxicity via multiple exposure routes (H302, H312, H332) along with skin and eye irritation (H315, H319). Its clinical development was discontinued due to hepatotoxicity concerns.

Known concerns

  • Prohibited at ≥0.1% in EU cosmetics
  • Acute oral toxicity H302
  • Liver toxicity concerns
  • Skin and eye irritation H315/H319
  • Inhalation toxicity H332

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.