Skin Conditioning
BICYCLIC S-KINOSHITA'S CONE OLIGOPEPTIDE-2 TRIFLUOROACETATE
Safety score · 0–100
Moderate
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A synthetic bicyclic peptide inspired by cone-snail toxin chemistry, stabilized as a trifluoroacetate salt. Novel ingredient with minimal public data.
This ingredient is a synthetic bicyclic peptide whose sequence and topology are modeled on the conotoxin family — a group of potent neuroactive peptides from cone snails (genus Conus) that target voltage-gated ion channels. Cosmetic interest centers on sequence-specific modulation of skin sensory receptors. The "bicyclic" designation indicates disulfide or lactam constraints that stabilize the 3D fold. The product is isolated as its trifluoroacetate salt (a common HPLC-purification counter-ion), which raises a PFAS-family sourcing concern if residual TFA is not removed. No CIR or SCCS review is available. Use is at very low concentration. Default-cautious scoring applies.
Skin benefits
- Synthetic bicyclic peptide inspired by cone-snail toxin chemistry
- Constrained scaffold for stability
- Very low cosmetic use concentrations
Known concerns
- Cone-snail peptides are inherently potent neurotoxins — class caution
- No CIR or SCCS review
- Trifluoroacetate salt is a manufacturing residue of concern (PFAS family)
- Essentially no public safety data
- Novel bicyclic cosmetic peptide technology
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related skin conditionings
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.