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demegestone

CAS 10116-22-0
10

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Demegestone is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Demegestone is a synthetic steroid hormone acting as a progesterone receptor modulator, used in pharmaceutical hormone replacement therapy. It is not authorised in any EU cosmetic annex and is considered prohibited under the general exclusion of endocrine-disrupting substances from cosmetic products, as outlined in the EU Chemicals Strategy for Sustainability. Its hormonal activity makes it entirely unsuitable for cosmetic formulations without medical supervision.

Known concerns

  • Endocrine-disrupting steroid hormone - prohibited pharmaceutical
  • No cosmetic function authorised in EU
  • Not evaluated by SCCS for cosmetic safety
  • Potential reproductive and developmental toxicity concerns

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.