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(R)-5-Bromo-3-(1-methyl-2-pyrrolidinylmethyl)-1H-indole

CAS 143322-57-0
10

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

This compound is a brominated indole alkaloid analogue with extensive hazard profiling: H302 (harmful if swallowed), H317 (may cause allergic skin reaction), H332 (harmful if inhaled), H361f (suspected fertility damage), H372 (organ damage with repeated exposure), H400/H410 (aquatic toxicity), H318 (causes serious eye damage), H361 (suspected developmental toxicity), H370 (organ damage). The combination of CMR classification, aquatic toxicity, and sensitisation alerts places this substance firmly in the restricted/banned category for cosmetic ingredients.

Known concerns

  • Fertility and developmental toxicity (H361f, H361)
  • Organ damage with repeated exposure (H372)
  • Skin sensitisation (H317)
  • Aquatic toxicity H400, H410
  • CMR profile precluding cosmetic use

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.