Other
doxapram
Safety score · 0–100
Avoid
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
Doxapram is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.
Doxapram is a respiratory stimulant (propylhexedrine derivative) used medically as a respiratory stimulant in post-anesthesia and COPD management. It acts on peripheral chemoreceptors to increase respiratory rate and depth. The ingredient is not approved for cosmetic use in any major market. EU Regulation 1223/2009 Annex II prohibits pharmacologically active substances not specifically authorized for cosmetic use. Doxapram's side effect profile includes hypertension, tachycardia, seizures, and psychiatric effects — entirely unsuitable for cosmetic application. No cosmetic function has been identified; any presence constitutes a regulatory violation.
Known concerns
- Pharmacologically active prescription drug - prohibited in cosmetics
- May cause CNS stimulation, seizures, hypertension
- No safety assessment for cosmetic topical use
- Subject to drug scheduling in most countries
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.