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4,4'-Bi-o-toluidine dihydrochloride

CAS 612-82-8
15

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Bi-o-toluidine dihydrochloride is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

4,4'-Bi-o-toluidine dihydrochloride (o-tolidine dihydrochloride) is a dimeric aromatic amine classified with H350 (suspected of causing cancer) and H411 (toxic to aquatic life with long-lasting effects). The biphenyl structure combined with aromatic amine functional groups creates significant concern for carcinogenicity through similar metabolic activation pathways as other aromatic amines. EU REACH regulation requires authorization for this substance, and cosmetic use is highly restricted.

Known concerns

  • H350 suspected carcinogen
  • H411 aquatic toxicity with long-lasting effects
  • CMR classification concern
  • Severe EU regulatory restrictions

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.