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Ethanol, 2-[(4-amino-2-methyl-5-nitrophenyl)amino]- and its salts

CAS 82576-75-8
52

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A nitro-amino aromatic compound used as a hair dye intermediate, it carries a skin sensitisation warning (H317) and is subject to specific concentration limits in the EU, particularly for oxidative hair dye applications where it functions as a secondary intermediate.

This 5-nitro-1,2-phenylenediamine derivative is a nitro-amino aromatic compound used as a coupling intermediate in oxidative hair dye systems. The nitro group combined with the aromatic amine structure gives rise to the H317 (skin sensitisation) classification. The EU CosIng entry lists a maximum concentration of 0.28%, which applies specifically to hair dye applications at the point of mixing. Nitro-phenylenediamines are subject to specific EU restrictions as hair dye intermediates and must be labelled with appropriate cautionary statements. The nitro group also raises theoretical concerns about phototoxicity and nitrosamine formation in combination with certain other ingredients.

Known concerns

  • H317: May cause allergic skin reaction (skin sensitisation)
  • EU concentration limit: 0.28% in hair dye formulations
  • Nitro-aromatic structure: theoretical nitrosamine formation concern in combination with secondary amines
  • Potential phototoxicity of nitroaromatic compounds

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.