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2-[(2-methoxy-4-nitrophenyl)amino]ethanol and its salts

CAS 66095-81-6
52

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A nitro-substituted phenyl ether used as a hair dye intermediate, carrying mild systemic toxicity concern and regulated to 0.2% maximum in EU-approved hair dye formulations.

This nitroaminoethoxybenzene compound is an oxidative hair dye intermediate of the nitroamino-benzene class, structurally related to HC Yellow No. 2. Nitro groups on aromatic amines contribute to high tinctorial strength but also potential sensitisation and, under metabolic activation, genotoxicity concern. The 0.2% maximum concentration (as the free base) reflects the EU SCCS assessment for this structural class, which places it under general oxidative hair dye safety provisions. No GHS hazard statements were provided in the source data.

Known concerns

  • Potential skin sensitisation (nitro-aromatic amine)
  • Possible genotoxicity concern under metabolic activation

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

Related others

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.