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Not permitted in cosmetics

fluocinonide

CAS 356-12-7
6

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A potent prescription corticosteroid drug — not a cosmetic ingredient. Must never appear in over-the-counter skincare; presence indicates illegal adulteration.

Fluocinonide (CAS 356-12-7) is a fluorinated, potent (class II in the US / class III EU) topical corticosteroid used as a prescription medicine for inflammatory dermatoses. It is classified as a pharmaceutical agent, not a cosmetic, in the EU (not on CosIng as permitted cosmetic use) and US (Rx drug). Repeated or unsupervised use causes skin atrophy, telangiectasia, striae, perioral dermatitis, and, on large surface areas or under occlusion, measurable HPA-axis suppression. Detection in cosmetics is a known adulteration pattern in unregulated brightening products and triggers regulatory recalls.

Skin benefits

  • Prescription anti-inflammatory activity (not a cosmetic benefit)

Known concerns

  • Potent class-II topical corticosteroid — prescription-only drug
  • Skin atrophy, telangiectasia, striae with repeated use
  • HPA-axis suppression risk in extended use
  • Not permitted in cosmetic products in EU/US
  • Rebound dermatitis on discontinuation

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.