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Fluperolone acetate [USAN]

CAS 2119-75-7
10

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Fluperolone acetate [USAN] is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Fluperolone acetate is a fluorinated synthetic corticosteroid related to prednisolone, featuring a 21-acetate ester and 6-alpha-fluoro substitution conferring enhanced anti-inflammatory potency. Corticosteroids are among the most stringently restricted substance categories in cosmetics — they are classified as substances with pharmacological action (Article 14 of EU Regulation 1223/2009) and have no legitimate cosmetic use. Topical corticosteroid adverse effects include skin atrophy, striae, telangiectasia, and systemic absorption leading to HPA axis suppression.

Known concerns

  • Synthetic corticosteroid — prohibited substance with pharmacological action
  • Skin atrophy and thinning with topical use
  • Systemic HPA axis suppression risk
  • Telangiectasia and striae formation risk
  • No safe cosmetic use — EU cosmetics prohibition applies

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.