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Glycyclamide (INN)

CAS 664-95-9
15

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Glycyclamide (INN) is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Glycyclamide (also known as glyhexamide) is a sulfonylurea-type oral hypoglycemic agent used for treating Type 2 diabetes, acting by stimulating insulin release from pancreatic beta cells. Its pharmacological mechanism as a systemic drug categorically excludes it from cosmetic use under EU Regulation (EC) No 1223/2009, which prohibits substances with medicinal activity. While not formally listed by CAS in the Annexes, its drug status and systemic effects place it outside the scope of permitted cosmetic ingredients.

Known concerns

  • Systemic antidiabetic drug — not permitted in cosmetics
  • Risk of hypoglycemia if absorbed through skin
  • Pharmacological action prohibited under EU cosmetic law

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.