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medroxyprogesterone

CAS 520-85-4
15

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A synthetic progestogen with CMR classification, banned from cosmetic use under EU Annex II and restricted to prescription pharmaceutical use.

Medroxyprogesterone acetate is a synthetic progestogen used in hormonal contraceptives and hormone replacement therapy. It is classified as CMR Category 1B under EU CLP and is explicitly banned under EU Cosmetics Regulation Annex II. Its endocrine-disrupting properties make it wholly unsuitable for cosmetic skin care formulations.

Known concerns

  • CMR Category 1B substance
  • Banned under EU Cosmetics Regulation Annex II
  • Endocrine disrupting properties
  • Thrombogenic risk

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.