Other
Nitrogen mustard N-oxide hydrochloride
Safety score · 0–100
Avoid
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A reactive alkylating agent and nitrogen mustard derivative with potent cytotoxic and vesicant properties, functioning as a chemotherapy agent; completely prohibited from cosmetic use due to extreme toxicity.
Nitrogen mustard N-oxide hydrochloride is a derivative of mechlorethamine (bis(2-chloroethyl)methylamine) where the tertiary amine is oxidised to an N-oxide. Nitrogen mustards are potent alkylating agents that form DNA crosslinks, making them effective chemotherapeutic agents but also significant genotoxins and vesicants. They are classified as carcinogenic, mutagenic, and reprotoxic. The EU Cosmetics Regulation bans substances with such hazard profiles from cosmetic formulations entirely. This compound has no role, safety justification, or regulatory authorisation in any cosmetic product category.
Known concerns
- DNA alkylating agent — genotoxic and carcinogenic
- Strong vesicant causing severe skin burns and blistering
- No EU cosmetic authorisation — pharmaceutical chemotherapy agent
- Environmental hazard due to extreme persistence and toxicity
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related others
Check your shelf
Find Nitrogen mustard N-oxide hydrochloride in your products.
Scan any cosmetic product with LuxSense to see if it contains Nitrogen mustard N-oxide hydrochloride and get a full ingredient breakdown with safety scores.
This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.