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p-Phenylenediamine and its salts

CAS 106-50-3 / 624-18-0 / 16245-77-5
15

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

P-Phenylenediamine and its salts is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

p-Phenylenediamine (PPD) is the archetype hair dye intermediate, extensively studied yet persistently concerning. EU Regulation 1223/2009 Annex III permits PPD in oxidative hair dye formulations only at up to 2% concentration after mixed with hydrogen peroxide, with mandatory pre-test warnings and prohibition from use in eyelash or eyebrow products. The extensive hazard profile includes acute oral, dermal, and inhalation toxicity (H301+H311+H331), skin sensitization (H317), serious eye damage (H318), and environmental hazards (H400+H410). The SCCS has repeatedly noted that consumer protection requires strict adherence to concentration limits and application conditions. PPD remains one of the most frequently reported causes of contact allergy from hair dyes, and professional use with appropriate protective measures is strongly recommended.

Known concerns

  • Acute toxicity H301+H311+H331 (oral, dermal, inhalation)
  • Skin sensitization H317 - one of most common hair dye allergens
  • Serious eye damage H318
  • Environmental hazard H400+H410
  • Frequent cause of contact allergy in hair dye users
  • Strict concentration and application restrictions apply

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.