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PHENACETIN

CAS 62-44-2
8

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Phenacetin is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Phenacetin is an older analgesic and antipyretic drug (p-phenetidin derivative) that was widely used in headache and pain remedies but was withdrawn from pharmaceutical markets due to severe adverse effects including nephrotoxicity (analgesic nephropathy), methemoglobinemia, and carcinogenicity. It is classified as a Category 1B carcinogen under EU CLP Regulation (EC) No 1272/2008. Under EU Regulation (EC) No 1223/2009, substances classified as CMR (Carcinogenic, Mutagenic, or Reprotoxic) Category 1A or 1B under CLP are prohibited in cosmetic products — phenacetin is banned in cosmetics in all EU member states.

Known concerns

  • Category 1B carcinogen under EU CLP Regulation (EC) No 1272/2008
  • Category 2 reproductive toxicant
  • Prohibited in cosmetic products under EU Regulation (EC) No 1223/2009 Annex II
  • Nephrotoxic (analgesic nephropathy)
  • Causes methemoglobinemia at high doses

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.