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2,2,2-Trichloroethane-1,1-diol

CAS 302-17-0
8

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Chloral hydrate — a withdrawn sedative drug that is an IARC Group 2A probable carcinogen. Not a cosmetic ingredient.

2,2,2-Trichloroethane-1,1-diol (chloral hydrate, CAS 302-17-0) is a sedative-hypnotic drug with a long but problematic history of medical use as an insomnia and pediatric sedation agent; it has been withdrawn from many markets on safety grounds (narrow therapeutic index, cardiac and respiratory depression, overdose lethality). IARC classifies chloral hydrate as Group 2A (probably carcinogenic to humans) on the basis of animal liver tumour evidence. It is not an authorised cosmetic ingredient and has no cosmetic function. Any listing in a cosmetic database reflects regulatory/CMR watch-listing rather than formulation use.

Skin benefits

  • None for cosmetic use

Known concerns

  • IARC Group 2A probable human carcinogen
  • Withdrawn sedative drug
  • Not a cosmetic ingredient
  • Systemic CNS toxicity

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

Related others

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.