Conditioning Agent
RH-POLYPEPTIDE-13
Safety score · 0–100
Good
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A recombinant human noggin protein analogue produced in E. coli, functioning as a BMP antagonist for skin conditioning.
Noggin is a secreted glycoprotein that antagonises bone morphogenetic proteins (BMPs) and regulates hair follicle and skin development. This recombinant analogue, subject to EU Annex II entry 416, is produced in E. coli with up to 232 amino acids. As a BMP antagonist, it modulates cell differentiation pathways. The EU regulatory framework classifies recombinant human proteins under the same peptide provisions as smaller polypeptides. Cosmetic use at low concentrations is generally considered safe, though noggin's role in developmental pathways warrants caution regarding unintended biological effects.
Function
Skin benefits
- May support skin homeostasis by modulating BMP signalling
- Potential benefits for hair follicle and skin regeneration
Known concerns
- BMP antagonist activity may interfere with normal skin differentiation processes at high concentrations
- E. coli endotoxin risk requires thorough purification
- Long-term topical safety data limited
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related conditioning agents
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.