Conditioning Agent
RH-POLYPEPTIDE-25
Safety score · 0–100
Good
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A recombinant human peptide modelled on interleukin-2, used in skincare for its cell-signalling and conditioning properties.
This recombinant human peptide mimics a portion of interleukin-2, a cytokine involved in immune cell proliferation and skin repair pathways. It is produced via E. coli fermentation and consists of a defined sequence of standard amino acids. Under EU Regulation 1223/2009, it is classified under the 'peptides' category (Annex II entry 416) with no specific concentration limit set, indicating general recognition of safety at cosmetic use levels when produced under GMP conditions.
Function
Skin benefits
- May support skin barrier repair through cytokine-like signalling
- Potential anti-ageing effects via collagen stimulation pathways
Known concerns
- Potential for immune sensitisation with prolonged use
- Quality control critical — endotoxin risk from E. coli expression system
- Insufficient long-term human safety data for chronic topical use
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related conditioning agents
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.