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TESTOSTERONE

CAS 58-22-0
10

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A potent androgenic hormone banned from cosmetic use in the EU, listed as a restricted pharmaceutical substance under Annex II/37 with no safe use in topical cosmetics.

Testosterone (17β-Hydroxy-4-Androsten-3-one, CAS 58-22-0) is a potent androgenic steroid hormone and is listed in EU Cosmetic Regulation Annex II (prohibited substances for cosmetic use). The restriction under Annex II/37 reflects the pharmaceutical drug status of this substance and the absolute prohibition against using hormones in cosmetic products without proper medical authorization. Testosterone as a cosmetic ingredient would be completely unacceptable due to its endocrine effects, developmental toxicity potential, and pharmaceutical classification as a prescription drug in most jurisdictions. Any cosmetic formulation containing testosterone would be in violation of EU Regulation 1223/2009.

Known concerns

  • EU Annex II banned substance - absolutely prohibited in cosmetics
  • Hazardous endocrine-disrupting hormone with systemic effects
  • Drug substance requiring medical prescription
  • No safe cosmetic use level exists

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.