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1,3,5-tris-[(2S and 2R)-2,3-Epoxypropyl]-1,3,5-triazine-2,4,6-(1H,3H,5H)-trione

CAS 59653-74-6
22

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A triglycidyl isocyanurate compound with severe toxicity including mutagenicity, skin and respiratory sensitization, explicitly restricted in EU.

1,3,5-tris-[(2S and 2R)-2,3-Epoxypropyl]-1,3,5-triazine-2,4,6-(1H,3H,5H)-trione (CAS 59653-74-6) is an epoxy-substituted triazine trione, structurally similar to TGIC. GHS hazard statements include H301 (toxic if swallowed), H302 (harmful if swallowed), H315 (causes skin irritation), H317 (may cause skin sensitization), H318 (causes serious eye damage), H319 (causes serious eye irritation), H331 (toxic if inhaled), H334 (may cause allergy or asthma if inhaled), H340 (may cause genetic defects), H361 (suspected of damaging fertility), H373 (may cause damage to organs), H412 (harmful to aquatic life). The substance shares TGIC's epoxy and triazine structure, giving it similar mutagenic and sensitization concerns. EU REACH restricts this substance. Cosmetic use is highly questionable and likely prohibited.

Known concerns

  • Mutagenic (H340)
  • Skin sensitization (H317)
  • Respiratory sensitization (H334)
  • Reproductive toxicity (H361)
  • Acute toxicity (H301, H331)
  • Aquatic toxicity (H412)

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.