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1,4-BUTANEDIOL

CAS 110-63-4
38

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

1,4-butanediol is a cosmetic ingredient. Exercise caution due to limited available safety data.

1,4-Butanediol (BDO) is a saturated diol used as a solvent and intermediate in cosmetic formulations. It carries GHS warnings for acute oral toxicity (H302) and CNS depression (H336: May cause drowsiness or dizziness). Importantly, BDO is metabolized to gamma-hydroxybutyrate (GHB), a controlled substance with abuse potential. The SCCS has issued opinions on BDO in cosmetic products. Concentration limits apply in some jurisdictions. EU Annex III may include restrictions.

Skin benefits

  • Humectant properties
  • Solvent
  • May improve product texture

Known concerns

  • Warning: H302 (Harmful if swallowed)
  • Warning: H336 (May cause drowsiness)
  • GHB precursor requiring regulatory attention
  • Concentration restrictions apply

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.