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1-Hydroxy-3-nitro- 4-(3-hydroxypropy lamino)benzene

CAS 92952-81-3
55

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A nitro aromatic hair dye intermediate with a maximum concentration limit of 2.6% in EU cosmetic formulations, used in oxidative hair coloration systems.

This nitro-substituted benzene derivative functions as a primary intermediate in oxidative hair dye formulations, producing color upon reaction with couplers and hydrogen peroxide. The 3-hydroxypropylamino substituent contributes to the color character and hair binding properties. EU regulation specifies a maximum concentration of 2.6% in the final cosmetic product, ensuring safe use levels. Nitro aromatic compounds in hair dyes undergo extensive safety testing and approval processes. The compound has no specific GHS hazard statements in the provided data, though standard handling precautions for hair dye intermediates apply.

Skin benefits

  • Primary intermediate in oxidative hair coloration
  • Produces warm color tones when combined with couplers
  • Enables permanent hair color formulations

Known concerns

  • Concentration restricted to 2.6% maximum in EU cosmetic products
  • Nitro aromatic compounds may cause sensitization
  • Hair dye intermediates require careful handling
  • Oxidative hair dyes can cause significant allergic reactions

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.