(1-Methylhexyl)ammonium sulphate
Safety score · 0–100
Moderate
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
An alkyl ammonium sulfate salt with local anesthetic properties, structurally related to ester-type anesthetics. Limited cosmetics use and safety data, with concern regarding potential hydrolysis to toxic byproducts.
(1-Methylhexyl)ammonium Sulphate is a secondary alkyl ammonium salt of sulfuric acid. The ester-type anesthetic structure of the parent 1-methylhexyl benzoate (amylocaine) has raised concerns, though this ammonium salt form may have different properties. It is not listed in EU Annex II (banned substances) or Annex III (restricted substances) of the Cosmetics Regulation, suggesting permitted use, but the limited data and structural alerts warrant caution. The sulphate counterion is generally considered safe, but the alkyl amine structure requires toxicological evaluation.
Known concerns
- Limited toxicological data for cosmetics use
- Potential for systemic absorption of the alkyl amine
- Ester-type anesthetic structural alerts
- Ammonium salt may affect skin barrier
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.