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Banned Substance

11-alpha-Hydroxypregn-4-ene-3,20-dione and its esters

CAS 80-75-1 Updated
4

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A hormonally active progesterone derivative used in pharmaceutical synthesis. Steroid hormones are categorically banned in EU cosmetics under Annex II.

Skin benefits

  • Pharmaceutical steroid intermediate, not a cosmetic

Known concerns

  • EU Annex II banned in cosmetics
  • Hormonally active progesterone derivative
  • Endocrine disruption risk
  • Not permitted in personal-care products

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.