2-[2-(4-Chlorophenyl)-2-phenylacetyl]indan 1,3-dione (chlorophacinone - ISO)
Safety score · 0–100
Avoid
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
An indanedione anticoagulant rodenticide with extreme acute toxicity and birth defects concerns, absolutely prohibited in cosmetic formulations.
Chlorophacinone is an indanedione-class rodenticide that acts as a vitamin K antagonist, causing fatal hemorrhage in rodents. The EU cosmetic regulation categorically prohibits this substance due to its H300/H310/H330 (extremely toxic by all exposure routes), H360D (birth defects), H372 (specific organ toxicity), and H400/H410 (aquatic toxicity) hazard classifications. It has no cosmetic function and is listed on Annex II of Regulation 1223/2009 as a prohibited substance.
Known concerns
- Extremely toxic by ingestion, skin contact, and inhalation (H300/H310/H330)
- Birth defects (H360D)
- Specific organ toxicity (H372)
- Vitamin K antagonism causing hemorrhage risk
- Very toxic to aquatic organisms (H400/H410)
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.