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2,4,6-tri-tert-butylphenol

CAS 732-26-3
58

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

2,4,6-tri-tert-butylphenol is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

2,4,6-Tri-tert-butylphenol (CAS 732-26-3) is a sterically hindered phenolic compound with antioxidant properties. GHS hazard statements include H411 (toxic to aquatic life with long-lasting effects), H361 (suspected of damaging fertility or the unborn child), H373 (may cause damage to organs through prolonged or repeated exposure). The substance appears in CosIng with some restrictions noted. The tert-butyl substitution provides stability but also raises concerns about bioaccumulation and endocrine activity. Has been flagged in EU for potential endocrine-disrupting properties. Concentration limits may apply in cosmetic products.

Skin benefits

  • Antioxidant protection against free radicals

Known concerns

  • Aquatic toxicity (H411)
  • Suspected reproductive toxicity (H361)
  • Potential endocrine disruption
  • Organ effects from repeated exposure

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.