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2,4,6-TRIMETHYL-3-CYCLOHEXENECARBALDEHYDE

CAS 1423-46-7
28

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A highly sensitizing aldehyde with multiple hazard statements including respiratory sensitization (H334), making it a significant concern for cosmetic formulations.

This trimethylcyclohexenecarbaldehyde carries a particularly concerning set of hazard statements: H317 (skin sensitization), H315 (skin irritation), H319 (eye irritation), H334 (may cause allergy or asthma symptoms if inhaled - respiratory sensitizer), H400 (very toxic to aquatic life), H412 (harmful to aquatic life). The combination of skin AND respiratory sensitization potential is especially significant, as respiratory allergens often pose greater societal health burden. The aldehyde functional group combined with the unsaturated ring structure creates a highly reactive Michael acceptor, explaining its strong sensitizing capacity.

Known concerns

  • H317 skin sensitization
  • H315 skin irritation
  • H319 eye irritation
  • H334 respiratory sensitization (asthma risk)
  • H400/H412 aquatic toxicity
  • Dual skin + respiratory sensitization

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.