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2,4-Diaminoanisole sulfate

CAS 39156-41-7
28

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A hair dye intermediate that has raised significant health concerns due to its potential to form carcinogenic breakdown products in the body.

2,4-Diaminoanisole sulfate is an aromatic amine used as a precursor in oxidative hair dye formulations. The EU CosIng database restricts its use under Annex III due to concerns about potential genotoxicity and the formation of nitrosamines during processing. France has maintained particularly strict positions on this substance, requesting EU evaluation due to carcinogenic risk classification.

Known concerns

  • Potential genotoxic metabolite (benzimidazole structure)
  • Can form N-nitroso compounds in formulations
  • Skin sensitization reported in hair dye users
  • EU Annex III restricted for hair dye use

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.