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Banned Substance

2,4-Dinitrophenol

CAS 51-28-5 Updated
1

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

2,4-DNP — an industrial nitrophenol notorious for fatal poisonings as an illegal weight-loss drug. Listed in EU Annex II — strictly banned in cosmetics. Acutely lethal at low doses.

Skin benefits

  • No legitimate benefit in cosmetics — banned

Known concerns

  • EU Annex II banned acute toxin
  • Uncouples mitochondrial oxidative phosphorylation
  • Fatal even in low oral doses
  • Mutagenic and reprotoxic

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.