2,4-Pyrimidinediamine, 3-oxide
Safety score · 0–100
Moderate
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A pyrimidine-based hair dye intermediate used at up to 1.5% concentration in oxidative hair dye formulations with limited safety data.
2,4-Pyrimidinediamine, 3-oxide (also called 2,4-diaminopyrimidine 3-oxide or PMD) is a hair dye intermediate containing both amino groups and an N-oxide function. The 1.5% maximum concentration listed in CosIng applies to oxidative hair dye systems where it is coupled with primary intermediates to form polymeric colorants. The N-oxide functionality introduces potential for photosensitization and reactive oxygen species generation. Safety data for this specific compound in cosmetic hair dye applications are limited, and it should be used only in properly formulated oxidative systems.
Known concerns
- N-oxide functionality - potential photosensitization
- Limited long-term sensitization data
- Requires oxidative coupling for safe use
- 1.5% max in oxidative hair dyes only
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.