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2-(4-tert-butylbenzyl) propionaldehyde

CAS 80-54-6
38

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A fragrance aldehyde (Lysmeral) with extensive hazard warnings including reproductive toxicity and environmental hazards, used at controlled concentrations in perfumes.

2-(4-tert-butylbenzyl) propionaldehyde (Lysmeral) carries one of the most extensive hazard profile among common fragrance materials, including H361 (reproductive toxicity), H411/H412 (aquatic toxicity), H315/H317 (skin irritation/sensitization), and H360 (reproductive toxicity). It is not listed in EU Annex III restrictions, but the H361 and H317 classifications are significant. The fragrance industry has established IFRA guidelines limiting its concentration. In the EU, it must be declared as a fragrance allergen above 0.001% in leave-on products.

Known concerns

  • Suspected reproductive toxicity (H361)
  • Skin sensitizer (H317)
  • Aquatic chronic toxicity (H411, H412)
  • Skin irritation (H315)
  • Fragrance allergen declaration required

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.