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2,5,5-TRIMETHYL-2-PHENYL-1,3-DIOXANE

CAS 5406-58-6
50

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

2,5,5-trimethyl-2-phenyl-1,3-dioxane is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

2,5,5-Trimethyl-2-phenyl-1,3-dioxane is an aromatic cyclic acetal used as a fragrance ingredient providing amber and woody notes. The GHS profile (H317 skin sensitization, H319 serious eye irritation) reflects the chemical reactivity of the acetal group and the phenyl substituent. The compound is not listed on any EU Annex (II prohibited, III restricted, or VI permitted preservatives), placing it in a regulatory gap—legal but with a safety signal that warrants caution. Its cyclic acetal structure may hydrolyze under acidic skin conditions, releasing aldehydes.

Known concerns

  • GHS H317: may cause skin sensitization (allergic contact dermatitis)
  • GHS H319: causes serious eye irritation
  • Acetal structure may hydrolyze on skin, releasing reactive aldehyde fragments

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.