2,5,6-TRIMETHYL-2-CYCLOHEXENONE
Safety score · 0–100
Moderate
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
2,5,6-TRIMETHYL-2-CYCLOHEXENONE is a cosmetic ingredient used in product formulation. Exercise caution due to limited available safety data.
2,5,6-Trimethyl-2-cyclohexenone is a tri-substituted alpha,beta-unsaturated ketone with the GHS hazard statements H226 (flammable liquid), H302 (harmful if swallowed), H315 (skin irritant), and H412 (harmful to aquatic life with long-lasting effects). The unsaturated ketone structure and three methyl substituents increase its reactivity and potential for Michael-type addition reactions with skin proteins.
Skin benefits
- Provides complex herbal-minty fragrance notes in cosmetic formulations
Known concerns
- GHS: H226 flammable, H302 acute oral toxicity, H315 skin irritant, H412 aquatic chronic toxicity
- Alpha,beta-unsaturated ketone is a structural alert for sensitization
- Reactive electrophilic center can form protein adducts in skin
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.