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2,5-Dinitrophenol

CAS 329-71-5
15

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

2,5-dinitrophenol is a cosmetic ingredient. Exercise caution due to limited available safety data.

2,5-Dinitrophenol (DNP) is a nitroaromatic compound that acts as a potent mitochondrial uncoupler, dramatically increasing metabolic rate. It has no pharmaceutical approval in most EU countries due to severe adverse effects including hyperthermia, agranulocytosis, and fatalities. It is not listed in EU approved cosmetic ingredient databases and is absolutely prohibited from cosmetic formulations.

Known concerns

  • Metabolic uncoupler (severe toxicity)
  • Hyperthermia risk
  • Agranulocytosis risk
  • No approved cosmetic or pharmaceutical use in EU
  • Prohibited in cosmetic products

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.