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2-Diethylaminoethyl 3-hydroxy-4-phenylbenzoate and its salts

CAS 3572-52-9
60

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A local anesthetic ester-type compound used in cosmetic formulations for sensory effects, with no specific EU restrictions identified in Annexes II or III of Regulation (EC) No 1223/2009.

This diethylaminoethyl ester of 3-hydroxy-4-phenylbenzoate functions as a topical anesthetic and anti-itch agent in cosmetic products. The tertiary amine structure and ester linkage are characteristic of local anesthetic compounds. Esters can occasionally cause sensitization, and the benzoate ester structure warrants monitoring for paraben-type concerns, though no direct paraben classification applies here. No specific EU restrictions were identified, suggesting permitted cosmetic use within standard safety parameters. The ingredient is relatively specialized and not widely used in mainstream cosmetics.

Skin benefits

  • Topical anesthetic - reduces sensation/discomfort
  • Anti-itch properties for calming formulations
  • May enhance consumer comfort in certain product types

Known concerns

  • Ester structure may cause sensitization in susceptible individuals
  • Topical anesthetic effect may mask irritation signals
  • Limited widespread safety data in cosmetic literature
  • Monitor for allergic reactions in sensitive populations

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.