2-HEXYLIDENECYCLOHEXAN-1-ONE
Safety score · 0–100
Moderate
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
2-HEXYLIDENECYCLOHEXAN-1-ONE is a cosmetic ingredient used in product formulation. Exercise caution due to limited available safety data.
2-Hexylidenecyclohexan-1-one is an alpha,beta-unsaturated ketone with a hexylidene (C6 chain with exocyclic double bond) substituent. The enone (conjugated ketone) system is characteristic of compounds that undergo Michael-type addition reactions with nucleophiles, including skin proteins, which may contribute to both fragrance allergenic potential and phototoxicity. It is not listed in EU Annex II or III of the Cosmetics Regulation, suggesting permitted use. The hexyl chain provides moderate lipophilicity.
Skin benefits
- Provides spicy, woody, or ionone-type fragrance notes
- Used in amber and woody fragrance compositions
Known concerns
- Alpha,beta-unsaturated ketone may act as a skin sensitizer
- Potential for Michael addition to skin proteins
- Limited comprehensive toxicological data
- Theoretical phototoxicity concern from enone system
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.