Antioxidant
2-MERCAPTONICOTINOYL GLYCINE
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A thiol-glycine conjugate based on mercaptonicotinic acid — a niche ingredient proposed for antioxidant and chelating activity. Limited independent safety data.
2-Mercaptonicotinoyl Glycine (CAS 2101538-28-5, PubChem CID 129245196) is the N-acyl glycine derivative of 2-mercaptonicotinic acid — a small thiol molecule with a pyridine carboxamide linked to glycine. Proposed cosmetic uses include antioxidant and metal-chelating activity from the thiol–pyridine motif, with the glycine linker improving water solubility. PubChem returns no GHS classification records for this CID, consistent with a non-notified niche ingredient. There is no CIR, SCCS or ECHA dossier. Free-thiol compounds can oxidise in formulation and, at high levels, present sensitization risk, though no clinical data exists. Kept in mid-yellow (70) given absence of adverse data balanced against very thin independent literature.
Function
Skin benefits
- Thiol-glycine conjugate — proposed antioxidant/chelating activity
- Small molecule without flagged PubChem GHS hazards
- Glycine moiety is benign
Known concerns
- Novel niche ingredient — limited independent peer-reviewed safety data
- Free-thiol compounds can oxidise and potentially sensitize at high use
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related antioxidants
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.