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Antioxidant/Fragrance

2-METHOXY-4-METHOXYMETHYL-PHENOL

CAS 5533-03-9
65

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A methoxymethyl-substituted guaiacol used in flavours, fragrances and as a minor antioxidant in cosmetic formulations. It has a low-hazard GHS profile but limited cosmetic-specific safety review by CIR or SCCS.

Skin benefits

  • Guaiacol/vanillin-related phenol with antioxidant potential
  • Possible flavour and fragrance contributor
  • Stable in oil and aqueous-alcohol systems

Known concerns

  • Phenolic structures can irritate sensitive skin at higher levels
  • Not formally reviewed by CIR or SCCS for cosmetics
  • Potential allergen risk shared with related guaiacol derivatives

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.