Skip to content

Other

2-METHOXY-P-PHENYLENEDIAMINE SULFATE

CAS 42909-29-5 / 66671-82-7
28

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A methoxy-substituted phenylenediamine hair dye precursor with multiple acute toxicity and irritation hazard warnings including Danger classification.

2-Methoxy-p-phenylenediamine sulfate is an aromatic amine hair dye intermediate with the GHS Danger signal word and multiple hazard classifications: H301 (toxic if swallowed), H315 (skin irritation), H319 (serious eye irritation), H332 (harmful if inhaled), and H335 (may cause respiratory irritation). The EU CosIng lists it under Annex III restrictions. This substance represents a class of methoxy-substituted PPD derivatives that the SCCS has deemed requiring particular caution, with recommended concentration limits well below 1% in finished hair dye products.

Skin benefits

  • Acts as a primary intermediate in oxidative hair dye formulations
  • Enables achievement of specific tone profiles in hair coloring

Known concerns

  • Acute oral toxicity (H301 - Toxic if swallowed)
  • Skin irritation (H315)
  • Serious eye irritation (H319)
  • Respiratory irritation (H332/H335)
  • EU Annex III listed with concentration restrictions
  • SCCS has flagged methoxy-substituted phenylenediamines for careful risk evaluation

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

Related others

28
1-(4’-Aminophenylazo)-2-methyl- 4-(bis-2-hydroxyethyl) aminobenzene
Other
 28
2,2'-Bioxirane (1,2:3,4-Diepoxybutane)
Other
 28
2-((2-METHYLAMINO)ETHOXY)-P-PHENYLENEDIAMINE
Other
 28
2-(2,2-DIMETHOXY)ETHOXY-P-PHENYLENEDIAMINE
Other
 28
2-(2-(2-METHOXYETHOXY)ETHOXY)-P-PHENYLENEDIAMINE
Other
 28
2-(2-OXOBUTOXY)-P-PHENYLENEDIAMINE
Other
 28
2-(2-PROPENYLOXY)-P-PHENYLENEDIAMINE
Other
 28
2-Butyryl-3-hydroxy-5-thiocyclohexan-3-yl-cyclohex-2-en-1-one
Other

Check your shelf

Find 2-METHOXY-P-PHENYLENEDIAMINE SULFATE in your products.

Scan any cosmetic product with LuxSense to see if it contains 2-METHOXY-P-PHENYLENEDIAMINE SULFATE and get a full ingredient breakdown with safety scores.

This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.