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2-METHOXYMETHYL-P-PHENYLENEDIAMINE SULFATE

CAS 337906-37-3
30

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A sulfate salt of a substituted p-phenylenediamine used in hair dye formulations; restricted in the EU due to sensitization and toxicological concerns.

This hair dye intermediate features a methoxymethyl substituent on the phenylenediamine core, present as the sulfate salt which enhances its water solubility for formulation purposes. The European Commission's scientific committee (SCCS) has evaluated similar phenylenediamine derivatives and concluded they present moderate concern for sensitization when used in oxidative hair dye systems. EU Annex III listing under Regulation 1223/2009 imposes specific purity requirements and concentration limits (typically up to 2% in oxidative formulations) to protect consumers from excessive exposure and potential allergic sensitization.

Known concerns

  • Skin sensitization potential
  • Sulfate salt may increase irritancy in some individuals
  • Potential for methoxy substituent to form reactive species
  • Overall toxicity profile requires further SCCS evaluation

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.