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2-Methoxypropanol

CAS 1589-47-5
42

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A glycol ether solvent with reported reproductive and developmental toxicity concerns that limits its suitability for leave-on skin care formulations.

2-Methoxypropanol (propylene glycol methyl ether, PGME) is classified under REACH as a substance of concern for reproductive toxicity (Repr. Cat. 2; R61). It readily penetrates the skin and has been associated with developmental effects in animal studies at concentrations above 5%. EU cosmetic regulation does not specifically ban it but its use in leave-on products is discouraged.

Known concerns

  • Reproductive toxicity (REACH Repr. Cat. 2)
  • Developmental toxicity at high doses
  • Readily skin-penetrating

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.