2-Methoxypropanol
Safety score · 0–100
Moderate
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
A glycol ether solvent with reported reproductive and developmental toxicity concerns that limits its suitability for leave-on skin care formulations.
2-Methoxypropanol (propylene glycol methyl ether, PGME) is classified under REACH as a substance of concern for reproductive toxicity (Repr. Cat. 2; R61). It readily penetrates the skin and has been associated with developmental effects in animal studies at concentrations above 5%. EU cosmetic regulation does not specifically ban it but its use in leave-on products is discouraged.
Known concerns
- Reproductive toxicity (REACH Repr. Cat. 2)
- Developmental toxicity at high doses
- Readily skin-penetrating
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.