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2-Nitroanisole

CAS 91-23-6
25

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

2-Nitroanisole is a cosmetic ingredient used in product formulation. Exercise caution due to limited available safety data.

2-Nitroanisole is an aromatic nitro compound with a methoxy substituent, used as a chemical intermediate in industrial synthesis. Animal studies have demonstrated carcinogenic activity, and it carries structural alerts for genotoxicity. The EU REACH regulation classifies it with concern, and under Cosmetics Regulation 1223/2009, substances with demonstrated carcinogenic activity in animals face significant restrictions in cosmetic formulations. The compound is not specifically listed in EU Annexes II or III but would be effectively prohibited in cosmetic products based on its hazard profile.

Known concerns

  • Carcinogenic activity demonstrated in animal studies
  • Structural alerts for genotoxicity
  • Effectively prohibited in EU cosmetic products under CMR provisions
  • Occupational hazard requiring strict handling controls

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.