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2-NONYN-1-AL DIMETHYLACETAL

CAS 13257-44-8
55

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

2-NONYN-1-AL DIMETHYLACETAL is a cosmetic ingredient used in product formulation. Exercise caution due to limited available safety data.

2-Nonyn-1-al Dimethylacetal is an acetal of a C9 acetylenic aldehyde (2-nonynal). The acetal group provides stability compared to the free aldehyde, as acetals hydrolyze slowly to release the parent aldehyde. The non-2-ynyl (acetylenic) group is metabolically unusual and raises concerns for bioactivation. It is listed in EU Annex III of the Cosmetics Regulation as a fragrance allergen, requiring declaration when present above threshold concentrations. The H317 classification confirms skin sensitization potential.

Skin benefits

  • Provides fatty, green, waxy, and violet-type fragrance notes
  • Used in sophisticated floral and green compositions

Known concerns

  • Skin sensitizer (H317)
  • EU Annex III fragrance allergen requiring declaration
  • Acetylenic structure may undergo metabolic activation
  • Acetal hydrolysis releases the parent aldehyde over time

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.