Skip to content

Prohibited aromatic amine

3,3'-Dimethoxybenzidine (ortho-Dianisidine) and its salts

CAS 119-90-4
5

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A benzidine-class aromatic amine and historical dye intermediate banned from cosmetics. Carries serious carcinogenicity and sensitization risk and has no legitimate use in beauty products.

Skin benefits

  • Historic industrial use as a dye intermediate
  • Of analytical interest in some laboratory assays

Known concerns

  • Aromatic amine classified as a probable human carcinogen (IARC 2B)
  • Prohibited in EU cosmetics under Annex II
  • Known skin sensitizer with bladder cancer associations from occupational exposure

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

Related prohibited aromatic amines

4
4-Methyl-m-phenylenediamine (Toluene-2,4-diamine) and its salts
Prohibited aromatic amine
 4
6-Methoxy-m-toluidine (p-Cresidine)
Prohibited aromatic amine
 6
N-2-Naphthylaniline
Prohibited aromatic amine
 8
4,4'-Carbonimidoylbis[N,N-dimethylaniline] and its salts
Prohibited aromatic amine

Check your shelf

Find 3,3'-Dimethoxybenzidine (ortho-Dianisidine) and its salts in your products.

Scan any cosmetic product with LuxSense to see if it contains 3,3'-Dimethoxybenzidine (ortho-Dianisidine) and its salts and get a full ingredient breakdown with safety scores.

This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.