3,4,5-Trimethoxyphenethylamine (Mescaline) and its salts

10

Avoid

CAS Number: 54-04-6

About 3,4,5-Trimethoxyphenethylamine (Mescaline) and its salts

A cosmetic ingredient. Exercise caution due to limited available safety data.

Detailed Analysis

Mescaline (3,4,5-trimethoxyphenethylamine) is a phenethylamine alkaloid and serotonergic hallucinogen found in peyote cactus (Lophophora williamsii) and other cacti. It is controlled under international drug conventions (UN 1961 Single Convention) and EU regulations. EU Annex III restricts its use in cosmetic products at ≥0.1% concentration. Its pharmacological activity as a 5-HT2A agonist with psychoactive properties makes cosmetic use entirely inappropriate.

Known Concerns

  • ⚠ Psychoactive hallucinogenic compound
  • ⚠ International drug control
  • ⚠ CNS effects
  • ⚠ Prohibited ≥0.1% in EU cosmetics

Safety Score

10

Avoid

Based on EU regulatory data, published safety research, and ingredient function analysis.

References

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EU CosIng Database

European Commission cosmetic ingredient registry

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This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.