3,4-DIHYDROXYBENZOYL DIPEPTIDE-49 AMIDE

Emollient

83

Good

About 3,4-DIHYDROXYBENZOYL DIPEPTIDE-49 AMIDE

A bioactive dipeptide conjugated to a catechol (dihydroxybenzoyl) group, combining antioxidant and humectant functions for comprehensive skin conditioning in anti-aging formulations.

Detailed Analysis

3,4-Dihydroxybenzoyl Dipeptide-49 Amide is produced by coupling 3,4-dihydroxybenzoic acid (a caffeic acid precursor / catechol) with Dipeptide-49 via amide bond formation at the peptide C-terminus. The dihydroxybenzoyl (catechol) moiety provides potent antioxidant activity via free radical scavenging, while the dipeptide backbone supports skin conditioning. This ingredient is not listed in EU Annexes II, III, or VI of Regulation 1223/2009, indicating no restriction. The catechol structure is sensitive to oxidation (browning), which may affect formulation color but does not pose a safety concern at typical use levels.

What It Does

SKIN CONDITIONING - EMOLLIENT HUMECTANT SKIN CONDITIONING SKIN PROTECTING

Skin Benefits

  • ✓ Skin conditioning — emollient: supports skin barrier integrity
  • ✓ Humectant: draws moisture to skin
  • ✓ Skin protecting: antioxidant activity from catechol moiety
  • ✓ Anti-aging: may protect against oxidative stress damage

Known Concerns

  • ⚠ Catechol group is oxidation-sensitive — may cause formulation discoloration over time
  • ⚠ Possible darkening effect on light-colored formulations

Safety Score

83

Good

Based on EU regulatory data, published safety research, and ingredient function analysis.

References

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EU CosIng Database

European Commission cosmetic ingredient registry

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This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.