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3,5,5-Trimethylcyclohex-2-enone (Isophorone)

CAS 78-59-1
30

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

3,5,5-Trimethylcyclohex-2-enone (Isophorone) is a cosmetic ingredient used in product formulation. Exercise caution due to limited available safety data.

3,5,5-Trimethylcyclohex-2-enone (Isophorone) carries a H351 (suspected carcinogen) classification along with H302 (acute toxicity), H319 (eye irritation), and H335 (respiratory irritation). It is not formally listed in EU cosmetic regulation Annexes, but its carcinogenicity classification under CLP requires caution. The EU SCCS would typically require detailed safety data before approving this ingredient in leave-on cosmetic products. Occupational exposure limits exist for this compound.

Known concerns

  • Suspected carcinogen (H351)
  • Acute toxicity (H302)
  • Eye irritation (H319)
  • Respiratory irritation (H335)
  • Skin irritation (H315)

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.