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Fragrance allergen (banned)

3 and 4-(4-Hydroxy-4-methylpentyl)cyclohex-3-ene-1-carbaldehyde

CAS 31906-04-4 / 51414-25-6
15

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Also known as HICC or Lyral, this floral muguet aldehyde is fully prohibited in EU cosmetics since 2021 because the SCCS classified it as one of the most potent fragrance contact allergens on the market.

Skin benefits

  • Historically valued for floral lily-of-the-valley fragrance note in fine perfumery
  • Imparted a fresh, muguet-like scent character to a wide range of cosmetic formulations

Known concerns

  • Banned in EU cosmetics since 23 August 2019 (sale) and 23 August 2021 (use) under Regulation (EU) 2017/1410
  • Listed in Annex II as one of the most potent fragrance contact allergens identified by the SCCS
  • Documented as responsible for the highest number of fragrance allergy cases in European clinics
  • No safe use level established; SCCS concluded it should not be present in cosmetic products

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

Same plant / compound family

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.