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3-Chloro-4-(3-fluorobenzyloxy)aniline

CAS 202197-26-0
22

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

This fluorinated benzyl ether of a chlorinated aniline is an industrial chemical with significant hazard classifications including suspected genotoxicity and aquatic toxicity, with no cosmetic regulatory approval.

3-Chloro-4-(3-fluorobenzyloxy)aniline is a halogenated aromatic amine with both chloro and fluoro substituents linked via a benzyloxy ether bridge. It carries multiple CLP hazard classifications: H302 (harmful if swallowed), H341 (suspected of causing genetic defects), H373 (may cause damage to organs through prolonged or repeated exposure), H315 (causes skin irritation), and H400/H410 (acute and chronic aquatic toxicity). The compound has no listing in EU cosmetics regulation, indicating no approved cosmetic use. Its complex heterocyclic structure with multiple halogen substituents raises significant concerns about persistence, bioaccumulation, and potential for metabolically released halides.

Known concerns

  • Suspected genotoxicity (H341)
  • Repeated dose organ toxicity (H373)
  • Skin irritation (H315)
  • Acute oral toxicity (H302)
  • Aquatic toxicity (H400/H410)
  • No EU cosmetic approval

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.