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3-HEXENAL

CAS 4440-65-7
55

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

3-HEXENAL is a cosmetic ingredient used in product formulation. Exercise caution due to limited available safety data.

3-Hexenal (leaf aldehyde) is an alpha,beta-unsaturated carbonyl compound responsible for the grassy green odor in many plants. Unsaturated aldehydes are intrinsically more reactive and allergenic than saturated counterparts due to Michael acceptor activity. The EU requires declaration of fragrance allergens, and compounds like hexenal fall under increased scrutiny due to their sensitizing potential. Data on safe concentrations in cosmetics is limited.

Skin benefits

  • Provides fresh green fragrance note

Known concerns

  • Known skin sensitizer (unsaturated aldehyde)
  • Michael acceptor - potential for protein reactivity
  • Limited human sensitization data at cosmetic concentrations

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.